Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer

Cancer Statistics, 2009

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2009 · 9.7K citations · Full text

Epidemiology Of Cancer, Pathology, Cancer Registration +18

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 3.8K citations · Full text

Inflammation, Cytokine, Inflammatory Disease +10

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

Weibo Luo, Hongxia Hu, Ryan Chang et al. · Cell · 2011 · 1.4K citations · Full text

Pyruvate Kinase M2, Signal Transduction, Biochemistry +13

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

Charles J. David, Mo Chen, Marcela C. Assanah et al. · Nature · 2009 · 1.2K citations · Full text

Transcriptional Regulation, Natural Sciences, Transcription Regulation +8