Experimental Biology and Medicine · 1951 · 35 citations · 0 references
AgricultureNutritionNutritional SciencesMicronutrient DeficiencyMicronutrient NutritionNutritional ToxicologyMicronutrient SupplementationVitamin B12 DeficiencyVitamin B12 PhysiologyVitamin PhysiologyVitamin SupplementationVitamins In FoodsAcute Carbon Monoxide ToxicityAntinutrient EffectsB VitaminsCarbon Tetrachloride NeurotoxicityCarbon Tetrachloride ToxicityProtein Energy UtilizationProtein Utilization EfficiencyVitamin B12 Requirement Physiology
Vit. E and vit. B12 can replace each other in promoting protein utilization and in protecting against acute carbon tetrachloride toxicity in young rats reared on 10% protein diets deficient in these factors. The vit. B12 requirement for protection against CCl4 is considerably higher than for growth. Folacin supplements, alone, had no effect, but, in the presence of vit. B12 or vit. E, this factor markedly improved protein utilization and growth. L-Cystine protected against the acute toxicity but a synergism between cystine and vit. E was not noted.