Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(β-amino ester) block copolymer micelles for cancer therapy

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Block copolymer micelles for drug delivery: design, characterization and biological significance

Kazunori Kataoka, Atsushi Harada, Yukio Nagasaki · Advanced Drug Delivery Reviews · 2001 · 3.5K citations

Pharmacy, Pharmaceutics, Pharmacokinetics +16

Acid pH in tumors and its potential for therapeutic exploitation.

Ian F. Tannock, Daniela Rotin · PubMed · 1989 · 1.6K citations

Medicine, Oncology, Pharmacology +16

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

L.E. Gerweck, Koushik Seetharaman · PubMed · 1996 · 1.1K citations

Medicine, Oncology, Pharmacology +15

Degradable Poly(β-amino esters):  Synthesis, Characterization, and Self-Assembly with Plasmid DNA

David M. Lynn, Róbert Langer · Journal of the American Chemical Society · 2000 · 913 citations

Natural Sciences, Biochemistry, Biotechnology +17