Aire regulates negative selection of organ-specific T cells

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Mark S. Anderson, Emily S. Venanzi, Ludger Klein et al. · Science · 2002 · 2.4K citations

Immunology, Immune Regulation, Antigen Processing +18

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

Martha S. Jordan, Alina C. Boesteanu, Amy J. Reed et al. · Nature Immunology · 2001 · 1.6K citations

Signal Transduction, Autoimmune Disease, Lymphocyte Development +11

Positional cloning of the APECED gene

Kentaro Nagamine, Pärt Peterson, Hamish S. Scott et al. · Nature Genetics · 1997 · 1.4K citations

Genetics, Gene Structure, Dna Replication +6

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

Johanna Aaltonen, Petra Björses, Jaakko Perheentupa et al. · Nature Genetics · 1997 · 1.2K citations

Autoimmune Disease, Novel Gene, Autoantibody Production +11

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

Pamela S. Ohashi, Stephan Oehen, Kurt Buerki et al. · Cell · 1991 · 1.2K citations

Viral Persistence, Virus Infection, Diabetes +11