Diarylsulfonamides as selective, non-peptidic thrombin inhibitors

What Can We Learn from Molecular Recognition in Protein–Ligand Complexes for the Design of New Drugs?

Hans‐Joachim Böhm, G. Klebe · Angewandte Chemie International Edition in English · 1996 · 324 citations

Pharmacy, Medicinal Chemistry, Drug Design +16

Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA

Hans Brandstetter, H.W. Hoeffken, Doris Grosse et al. · Journal of Molecular Biology · 1992 · 193 citations

Life Sciences, Biochemistry, Medicinal Chemistry +16

Enzyme flexibility, solvent and ‘weak’ interactions characterize thrombin–ligand interactions: implications for drug design

Richard A. Engh, Hans Brandstetter, Gudrun Sucher et al. · Structure · 1996 · 97 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

DERIVATIVES OF 4-AMINO-PYRIDINE AS SELECTIVE THROMBIN INHIBITORS

Wolfgang von der Saal, Ralf Kucznierz, Herbert Leinert et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 32 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Synthesis of conformationally-restricted boropeptide thrombin inhibitors

Joseph Cacciola, John M. Fevig, Richard Alexander et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 22 citations

Medicine, Biochemistry, Medicinal Chemistry +12