Frank Grams

X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design

Frank Grams, Peter Reinemer, James C. Powers et al. · European Journal of Biochemistry · 1995 · 172 citations

Life Sciences, Biochemistry, Medicinal Chemistry +15

Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor

Frank Grams, Mike Crimmin, Laurie Hinnes et al. · Biochemistry · 1995 · 166 citations

Life Sciences, Medicinal Chemistry, Pharmacology +11

Anti-Invasive, Antitumoral, and Antiangiogenic Efficacy of a Pyrimidine-2,4,6-trione Derivative, an Orally Active and Selective Matrix Metalloproteinases Inhibitor

Erik Maquoi, Nor Eddine Sounni, Laetitia Devy et al. · Clinical Cancer Research · 2004 · 155 citations · Full text

Medicine, Oncology, Pharmacology +12

Pyrimidine-2,4,6-Triones: A New Effective and Selective Class of Matrix Metalloproteinase Inhibitors

Frank Grams, Hans Brandstetter, S. D’Alò et al. · Biological Chemistry · 2001 · 142 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Structural implications for the role of the N terminus in the ‘superactivation’ of collagenases

Peter Reinemer, Frank Grams, Robert Huber et al. · FEBS Letters · 1994 · 137 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17