Concepedia

GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

Ian A. Prior, Angus Harding, Jun Yan, Judith C. Sluimer, Robert G. Parton, John F. Hancock

Nature Cell Biology · 2001 · 522 citations · 30 references

DOI

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References

30

All ras proteins are polyisoprenylated but only some are palmitoylated

John F. Hancock, Anthony I. Magee, Julie E. Childs et al. · Cell · 1989 · 1.8K citations

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Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

Thomas Harder, Peter Scheiffele, Paul Verkade et al. · The Journal of Cell Biology · 1998 · 1.2K citations · Full text

, , +16

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

John F. Hancock, Hugh Paterson, Christopher J. Marshall · Cell · 1990 · 1.1K citations

, , +8

Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

Asim Khwaja, Pablo Rodriguez‐Viciana, Stefan Wennström et al. · The EMBO Journal · 1997 · 1K citations · Full text

, , +16

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

Sally J. Leevers, Hugh F. Paterson, Christopher J. Marshall · Nature · 1994 · 1K citations

, , +9