Concepedia

Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse

J. E. Dinger, Markus R. Meyer, Hans H. Maurer

Toxicology Letters · 2014 · 46 citations · 35 references

DOI

Concepts

References

35

Cytochrome P450: Structure, mechanism, and biochemistry

W. A. PRYOR · Free Radical Biology and Medicine · 1996 · 1.6K citations

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Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism

Yvan Gasche, Youssef Daali, Marc Fathi et al. · New England Journal of Medicine · 2004 · 700 citations · Full text

, , +17

CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants

L M Hesse, Karthik Venkatakrishnan, Michael H. Court et al. · Drug Metabolism and Disposition · 2000 · 399 citations

, , +17

Concentrations of Tramadol and O-desmethyltramadol Enantiomers in Different CYP2D6 Genotypes

Ulrike M. Stamer, Makbule Kobilay, Burkhard Madea et al. · Clinical Pharmacology & Therapeutics · 2007 · 240 citations

, , +17

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

Elizabeth A. Dierks, Karen R. Stams, Heng‐Keang Lim et al. · PubMed · 2001 · 237 citations

, , +16