Concepedia

Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity

Hongjun Fu, Wenming Li, Jialie Luo, Nelson T.K. Lee, Mingtao Li, Karl Wah Keung Tsim, Yuan‐Ping Pang, Moussa B. H. Youdim, Yifan Han

Biochemical and Biophysical Research Communications · 2007 · 56 citations · 14 references

DOI

Concepts

References

14

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

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Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

Roger M. Nitsch, Barbara E. Slack, Richard J. Wurtman et al. · Science · 1992 · 899 citations

, , +17

Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

Yuan‐Ping Pang, Polly A. Quiram, Tanya M. Jelacic et al. · Journal of Biological Chemistry · 1996 · 346 citations · Full text

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Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells

Gopal Thinakaran, David B. Teplow, Robert Siman et al. · Journal of Biological Chemistry · 1996 · 316 citations · Full text

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Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation

Yanxiang Ni, Xiaohui Zhao, Guobin Bao et al. · Nature Medicine · 2006 · 238 citations

, , +15