Efficient somatic gene targeting in the lymphoid human cell line DG75

Selective extraction of polyoma DNA from infected mouse cell cultures

Bernhard Hirt · Journal of Molecular Biology · 1967 · 5.3K citations

Life Sciences, Cell Biology, Molecular Biology +11

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

Todd Waldman, K. W. Kinzler, Bert Vogelstein · PubMed · 1995 · 1.2K citations

Life Sciences, Cell Biology, Oncology +17

Bypass of Senescence After Disruption of p21 ^{<i>CIP1/WAF1</i>} Gene in Normal Diploid Human Fibroblasts

Jeremy Brown, Wenyi Wei, John M. Sedivy · Science · 1997 · 803 citations

Life Sciences, Genetics, Molecular Genetics +17

Homologous recombination in human embryonic stem cells

Thomas P. Zwaka, James A. Thomson · Nature Biotechnology · 2003 · 666 citations

Life Sciences, Cell Biology, Developmental Biology +10