Concepedia

Somatic Mutation Targeting

Somatic Mutation Targeting is a precision genome editing strategy that specifically modifies disease-causing mutations in somatic cells without altering germline DNA, thereby enabling therapeutic intervention while preserving the individual’s heritable genetic information.

89

Publications

7K

Citations

643

Authors

272

Institutions

Publications per year

2017–2026

23

Parents

Publications

89

Natural History of Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen, S. M. Lewis, Monica Bessler et al. · New England Journal of Medicine · 1995 · 901 citations · Full text

, , +14

Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies

Michael C. Heinrich · Journal of Clinical Oncology · 2002 · 580 citations

, , +17

Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

Gaelen T. Hess, Laure Frésard, Kyuho Han et al. · Nature Methods · 2016 · 483 citations · Full text

, , +7

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

Cristina Rada, Michael R. Ehrenstein, Michael S. Neuberger et al. · Immunity · 1998 · 353 citations · Full text

, , +7

The WHIM-like CXCR4S338X somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia

Yang Cao, Zachary R. Hunter, Xingguang Liu et al. · Leukemia · 2014 · 234 citations

, , +7

1–5 of 89

Authors

643

  1. MS
    Michael S. Neuberger

    MRC Laboratory of Molecular Biology, United Kingdom

    3 publications · 615 citations

    3

    h-index

  2. YW
    Yang Wang

    Tianjin Medical University General Hospital, China

    2 publications · 58 citations

    2

    h-index

  3. PE
    Peter E. Lipsky

    The University of Texas Southwestern Medical Center, United States

    2 publications · 96 citations

    2

    h-index

  4. HM
    Hector Molina

    Washington University in St. Louis, United States

    2 publications · 58 citations

    2

    h-index

  5. DC
    David Chaplin

    Howard Hughes Medical Institute, United States

    2 publications · 58 citations

    2

    h-index

1–5 of 643

Institutions

272

  1. National Institutes of Health

    Bethesda, United States

    5 h-index

    17 publications

    436 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    8 publications

    621 citations

  3. Yale University

    New Haven, United States

    3 h-index

    6 publications

    498 citations

  4. Duke Medical Center

    Durham, United States

    3 h-index

    5 publications

    507 citations

  5. Washington University in St. Louis

    St Louis, United States

    3 h-index

    5 publications

    274 citations

  6. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    14 publications

    2.7K citations

  7. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    3 h-index

    17 publications

    3.6K citations

  8. Baylor College of Medicine

    Houston, United States

    3 h-index

    6 publications

    426 citations

1–8 of 272

Venues

  1. The Journal of Immunology

    JI · 5 publications · 228 citations

    5

    h-index

  2. Blood

    4 publications · 241 citations

    4

    h-index

  3. PubMed

    Repository · 4 publications · 132 citations

    4

    h-index

  4. The Journal of Experimental Medicine

    4 publications · 325 citations

    4

    h-index

  5. European Journal of Immunology

    EJI · 3 publications · 95 citations

    3

    h-index

1–5