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The WHIM-like CXCR4S338X somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia

Somatic VariantNovel TherapyMedicineImmunologyOther AgentsPathologyWaldenstrom ’ImmunotherapyCell SignalingInborn Error Of Immunity