Evidence for a Novel Feedback Loop in the Hedgehog Pathway Involving Smoothened and Fused

Expression of engrailed proteins in arthropods, annelids, and chordates

Nipam H. Patel, Enrique Martı́n-Blanco, Kevin Coleman et al. · Cell · 1989 · 1K citations

Biology, Developmental Biology, Integrative Biology +5

Dual Roles for Patched in Sequestering and Transducing Hedgehog

Yu Chen, Gary Struhl · Cell · 1996 · 904 citations · Full text

Patched acts catalytically to suppress the activity of Smoothened

Jussi Taipale, Michael K. Cooper, Tapan Maiti et al. · Nature · 2002 · 794 citations

Catalysis, Chemistry, Homogeneous Catalysis

Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor

Pedro Aza‐Blanc, Felipe-Andrés Ramı́rez-Weber, Marie-Pierre Laget et al. · Cell · 1997 · 661 citations · Full text

Biology, Protein Function, Developmental Biology +7

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

Natalie Denef, Dagmar Neubüser, Lídia Pérez et al. · Cell · 2000 · 529 citations · Full text

Biology, Molecular Physiology, Developmental Biology +9