Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication

Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

Robert W. Sidwell, John H. Huffman, Lois G. P. Khare et al. · Science · 1972 · 976 citations

Antiviral Agents, Broad-spectrum Antiviral Activity, Synthetic Virology +12

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

Jingshan Ren, Robert Esnouf, Elspeth F. Garman et al. · Nature Structural & Molecular Biology · 1995 · 498 citations

Biochemistry, Natural Sciences, Human Retrovirus +8

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

Tadashi Miyasaka, Hiromichi Tanaka, Masanori Baba et al. · Journal of Medicinal Chemistry · 1989 · 378 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Novel Lead +15

The non‐immunosuppressive cyclosporin DEBIO‐025 is a potent inhibitor of hepatitis C virus replication in vitro†

Jan Paeshuyse, Artur Kaul, Erik De Clercq et al. · Hepatology · 2006 · 273 citations · Full text

Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides:  Application of the Suzuki−Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids

Michal Hocek, Ivan Votruba, Hana Dvořáková · Journal of Medicinal Chemistry · 2000 · 200 citations

Cross-coupling Reaction, Pharmaceutical Chemistry, Engineering +14