Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

TLR4 links innate immunity and fatty acid–induced insulin resistance

Hang Shi, Maia V. Kokoeva, Karen Inouye et al. · Journal of Clinical Investigation · 2006 · 3.6K citations · Full text

Tlr4 Links, Immune Regulation, Immunology +16

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.3K citations · Full text

Toll-like Receptors, Gram-negative Bacteriology, Virulence Factor +7

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Insulin Resistance, Metabolic Syndrome, Obesity +10

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Dongsheng Cai, Minsheng Yuan, Daniel Frantz et al. · Nature Medicine · 2005 · 2.2K citations · Full text

Inflammation, Metabolic Syndrome, Insulin Resistance +15

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

Minsheng Yuan, Nicky Konstantopoulos, Jongsoon Lee et al. · Science · 2001 · 1.9K citations