Concepedia

The Role of Shear-Induced Transforming Growth Factor-β Signaling in the Endothelium

Tony E. Walshe, Nathaniel G. dela Paz, Patrìcia A. D'Amore

Arteriosclerosis Thrombosis and Vascular Biology · 2013 · 69 citations · 56 references

DOIFull text

Open access

Abstract

Shear stress of HUVECs induces TGF-β3 signaling and subsequent activation of Krüppel-like factor 2 and NO, and represents a novel role for TGF-β3 in the maintenance of HUVEC homeostasis in a hemodynamic environment.

References

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Soluble endoglin contributes to the pathogenesis of preeclampsia

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Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

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PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

Karen K. Hirschi, Stephanie A. Rohovsky, Patrìcia A. D'Amore · The Journal of Cell Biology · 1998 · 789 citations · Full text