IL18 polymorphism is associated with an increased risk of Crohn’s disease

Cloning of a new cytokine that induces IFN-γ production by T cells

Haruki Okamura, Hiroko Tsutsui, Toshinori Komatsu et al. · Nature · 1995 · 2.6K citations

Immune Cell Development, Immunology, Immune Regulation +10

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

Tariq Ghayur, Subhashis Banerjee, Margaret Hugunin et al. · Nature · 1997 · 1.2K citations

Cytokine, Transcriptional Regulation, Signal Transduction +10

Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

Yong Gu, Keisuke Kuida, Hiroko Tsutsui et al. · Science · 1997 · 1.1K citations

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

Jean‐Pierre Hugot, Pierre Laurent‐Puig, Corinne Gower‐Rousseau et al. · Nature · 1996 · 952 citations

Disease Susceptibility, Disease Mechanism, Genetics +9

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.

Curt Tysk, Eva Hellström Lindberg, G Järnerot et al. · Gut · 1988 · 827 citations · Full text

Disease Susceptibility, Autoimmune Disease, Swedish Twin Registry +13