T cell activation by recombinant FcεRI γ-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Zelig Eshhar, Tova Waks, G. Gross et al. · Proceedings of the National Academy of Sciences · 1993 · 1.6K citations

Life Sciences, Immunology, Oncology +17

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

Patrick Hwu, James C. Yang, R Cowherd et al. · PubMed · 1995 · 275 citations

Life Sciences, Immunology, Oncology +17

Hodgkin's disease: Establishment and characterization of four in vitro cell lines

Volker Diehl, Hartmut Kirchner, M. Schaadt et al. · Journal of Cancer Research and Clinical Oncology · 1981 · 157 citations · Full text

Engineering, Cell Biology, Oncology +10

Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression

Uwe Altenschmidt, Elfriede Klundt, Bernd Groner · The Journal of Immunology · 1997 · 114 citations · Full text

Life Sciences, Immunology, Oncology +13

A spacer region between the single chain antibody- and the CD3 zeta-chain domain of chimeric T cell receptor components is required for efficient ligand binding and signaling activity.

Dirk Moritz, Bernd Groner · PubMed · 1995 · 99 citations

Life Sciences, Immunology, Molecular Biology +12