Andreas Hombach

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Markus Chmielewski, Caroline Kopecky, Andreas Hombach et al. · Cancer Research · 2011 · 526 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +26

Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule

Andreas Hombach, Anja Wieczarkowiecz, Thomas Marquardt et al. · The Journal of Immunology · 2001 · 290 citations · Full text

T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity

Markus Chmielewski, Andreas Hombach, Claudia Heuser et al. · The Journal of Immunology · 2004 · 261 citations · Full text

Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

Barbara Savoldo, Cliona M. Rooney, Antonio Di Stasi et al. · Blood · 2007 · 235 citations · Full text

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response

Andreas Hombach, Andreas Hombach, Hinrich Abken · Gene Therapy · 2010 · 223 citations · Full text

T Cells, Immunology, Antigen Processing +10