Hinrich Abken

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Markus Chmielewski, Caroline Kopecky, Andreas Hombach et al. · Cancer Research · 2011 · 526 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +26

CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

Markus Chmielewski, Hinrich Abken · Cell Reports · 2017 · 402 citations · Full text

Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule

Andreas Hombach, Anja Wieczarkowiecz, Thomas Marquardt et al. · The Journal of Immunology · 2001 · 290 citations · Full text

T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity

Markus Chmielewski, Andreas Hombach, Claudia Heuser et al. · The Journal of Immunology · 2004 · 261 citations · Full text

Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

Barbara Savoldo, Cliona M. Rooney, Antonio Di Stasi et al. · Blood · 2007 · 235 citations · Full text