Concepedia

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response

Andreas Hombach, Andreas Hombach, Hinrich Abken

Gene Therapy · 2010 · 223 citations · 19 references

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References

19

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

Laura A. Johnson, Richard A. Morgan, Mark E. Dudley et al. · Blood · 2009 · 1.4K citations · Full text

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

Michael H. Kershaw, Jennifer A. Westwood, Linda L. Parker et al. · Clinical Cancer Research · 2006 · 1.2K citations · Full text

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Robert L. Shields, Angela K. Namenuk, Kyu Hong et al. · Journal of Biological Chemistry · 2001 · 1.1K citations · Full text

Adoptive Transfer of Chimeric Antigen Receptor Re-directed Cytolytic T Lymphocyte Clones in Patients with Neuroblastoma

Julie R. Park, David DiGiusto, Marilyn L. Slovak et al. · Molecular Therapy · 2007 · 593 citations · Full text

Noninvasive detection of therapeutic cytolytic T cells with 18F–FHBG PET in a patient with glioma

Shahriar Yaghoubi, Michael C. Jensen, Nagichettiar Satyamurthy et al. · Nature Clinical Practice Oncology · 2008 · 361 citations · Full text

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