Science · 1998 · 791 citations · 19 references
Life SciencesCell BiologyMolecular BiologyCell SignalingProtein-protein InteractionsSignal TransductionCell Signaling NetworksPhosphoinositide SignalingProtein Kinase CascadesReceptor Tyrosine Kinase SignalingSmall Gtpase SignalingC-jun N-terminal Kinase SignalingGuanosine Triphosphatase RegulationJun N-terminal Kinase SignalingMap KinasesPhosphatidylinositol 3, 4, 5-Trisphosphate SignalingPi3k SignalingRas Signaling ActivationRas-mitogen-activated Protein Kinase Signaling
Mitogen stimulation of cytoskeletal changes and c-jun amino-terminal kinases is mediated by Rac small guanine nucleotide-binding proteins. Vav, a guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange factor for Rac that stimulates the exchange of bound GDP for GTP, bound to and was directly controlled by substrates and products of phosphoinositide (PI) 3-kinase. The PI 3-kinase substrate phosphatidylinositol-4,5-bisphosphate inhibited activation of Vav by the tyrosine kinase Lck, whereas the product phosphatidylinositol-3,4,5-trisphosphate enhanced phosphorylation and activation of Vav by Lck. Control of Vav in response to mitogens by the products of PI 3-kinase suggests a mechanism for Ras-dependent activation of Rac.
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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B
David Stokoe, Terry Copeland, Piers R. J. Gaffney et al. · Science · 1997 · 1.2K citations
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
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Multiple ras functions can contribute to mammalian cell transformation
Michael A. White, Charles A. Nicolette, Audrey Minden et al. · Cell · 1995 · 650 citations · Full text