Old drugs as lead compounds for a new disease? Binding analysis of SARS coronavirus main proteinase with HIV, psychotic and parasite drugs

Coronavirus Main Proteinase (3CL ^pro ) Structure: Basis for Design of Anti-SARS Drugs

K. Anand, John Ziebuhr, Parvesh Wadhwani et al. · Science · 2003 · 1.8K citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

LGA: a method for finding 3D similarities in protein structures

Nucleic Acids Research · 2003 · 1.1K citations · Full text

Life Sciences, Biochemistry, Bioinformatics +14

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

Haitao Yang, Maojun Yang, Yi Ding et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Life Sciences, Biochemistry, Infectious Diseases +17

Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study.

KH Chan, S. T. Lai, Chung‐Ming Chu et al. · PubMed · 2003 · 443 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS

Kuo‐Chen Chou, Dong‐Qing Wei, Wei-Zhu Zhong · Biochemical and Biophysical Research Communications · 2003 · 311 citations

Life Sciences, Infectious Diseases, Molecular Biology +14