Simultaneous determination of the carboxylate and lactone forms of 10-hydroxycamptothecin in human serum by restricted-access media high-performance liquid chromatography

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Chemoprevention Strategy, Novel Alkaloidal Leukemia, Altmetric Attention Score +21

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

Julianne Fassberg, Valentino J. Stella · Journal of Pharmaceutical Sciences · 1992 · 462 citations

Engineering, Biotransformation, Biochemistry +9

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

Thomas G. Burke, Zihou Mi · Journal of Medicinal Chemistry · 1994 · 326 citations

Pharmaceutical Science, Lactone Forms, Pharmaceutical Chemistry +19

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

Seigo Sawada, Satoru Okajima, Ritsuo Aiyama et al. · Chemical and Pharmaceutical Bulletin · 1991 · 232 citations · Full text

Antitumor Activity, Novel 36, Organic Chemistry +16