TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong, +3

Nature

Signal TransductionSignaling PathwayCell RegulationProtein KinaseMedicine +4

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider, +3

Cell

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

Nikolay Malinin, Mark Boldin, A. V. Kovalenko, +1

Nature

InflammationCytokineSignal TransductionCell RegulationMap3k-related Kinase +12

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

Chrisostomos Prodromou, S. Mark Roe, Ronan O’Brien, +3

Cell

Atp/adp-binding SiteStructural CharacterizationProtein FunctionProtein AssemblyBiochemistry +9

Regulation of JNK signaling by GSTp

Victor Adler

The EMBO Journal

Signal TransductionSignaling PathwayReceptor Tyrosine KinaseCellular Regulatory MechanismCellular Biochemistry +4

A physical and functional map of the human TNF-α/NF-κB signal transduction pathway

Tewis Bouwmeester, Angela Bauch, Heinz Ruffner, +25

Nature Cell Biology

InflammationTranscriptional RegulationMolecular PhysiologySignal TransductionSignaling Pathway +12

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

Calin Dan Dumitru, Jeffrey D. Ceci, Christos Tsatsanis, +8

Cell

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationImmune Regulation +8

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

Frank S. Lee, Jeremiah Hagler, Zhijian J. Chen, +1

Cell

Iκbα Kinase ComplexSignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase +9

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

Andrea Basso, David B. Solit, Gabriela Chiosis, +3

Journal of Biological Chemistry

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis

Wolfgang M.J. Obermann, Holger Sondermann, Alicia A. Russo, +2

The Journal of Cell Biology

Protein AssemblyMolecular BiologyAtp BindingHsp90 FunctionCellular Physiology +16