Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3K citations

Signal Transduction, Signaling Pathway, Cell Regulation +5

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Laura Listenberger, Xianlin Han, Sarah E. Lewis et al. · Proceedings of the National Academy of Sciences · 2003 · 2K citations · Full text

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim et al. · Science · 2001 · 1.8K citations

Metabolic Disorder, Homeostatic Mechanism, Glucose Homeostasis +20

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Brendan D. Manning, Andrew R. Tee, M. Nicole Logsdon et al. · Molecular Cell · 2002 · 1.5K citations · Full text

Signal Transduction, Signaling Pathway, Pathology +9

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

Aimee D. Kohn, Scott A. Summers, Morris J. Birnbaum et al. · Journal of Biological Chemistry · 1996 · 1.3K citations · Full text

Glucose Transporter 4, Glucose Influx, Signal Transduction +14