Brendan D. Manning

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon et al. · Molecular Cell · 2010 · 1.9K citations · Full text

Metabolic Network, Systems Biology, Signal Transduction +9

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

Brendan D. Manning, Andrew R. Tee, M. Nicole Logsdon et al. · Molecular Cell · 2002 · 1.5K citations · Full text

Signal Transduction, Signaling Pathway, Pathology +9

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, Kui Lei, Rebecca L. Hurley et al. · Genes & Development · 2004 · 1.4K citations · Full text

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Andrew R. Tee, Brendan D. Manning, Philippe P. Roux et al. · Current Biology · 2003 · 1.2K citations · Full text

Protein Function, Signal Transduction, Gtpase-activating Protein Complex +7

The LKB1 tumor suppressor negatively regulates mTOR signaling

Reuben J. Shaw, Nabeel Bardeesy, Brendan D. Manning et al. · Cancer Cell · 2004 · 1.1K citations · Full text

Signal Transduction, Signaling Pathway, Lkb1 Tumor Suppressor +6