Transcriptional Regulation of BACE1 by NFAT3 Leads to Enhanced Amyloidogenic Processing

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

Maj-Linda B. Selenica, Milene L. Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases · 2012 · 10.4K citations · Full text

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1K citations

Protein Secretion, Signal Transduction, Molecular Neuroscience +8

β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

Hiroaki Fukumoto · Archives of Neurology · 2002 · 704 citations

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression

Xiulian Sun, Guiqiong He, Hong Qing et al. · Proceedings of the National Academy of Sciences · 2006 · 585 citations · Full text

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

Chia-Hsiung Chen, Weihui Zhou, Shengchun Liu et al. · The International Journal of Neuropsychopharmacology · 2011 · 412 citations · Full text

Therapeutic Potential, Sporadic Alzheimer, Immunology +25