Concepedia

Timing Is Critical for an Effective Anti-Metastatic Immunotherapy: The Decisive Role of IFNγ/STAT1-Mediated Activation of Autophagy

Jun Yan, Ziyan Wang, Hong-Zhen Yang, Han-Zhi Liu, Su Mi, Xiao-Xi Lv, Xiao-Ming Fu, Hui-Min Yan, Xiao-Wei Zhang, Qi-Min Zhan,

PLoS ONE · 2011 · 35 citations · 28 references

DOI Full text

Open access

Abstract

Our studies suggest that activation of IFNγ/STAT1 signaling and induction of autophagy are critical for an efficacious anti-metastatic immunotherapy and that autophagy activators may overcome the timing barrier for immunotherapy against metastasis.

References

28

Cancer Statistics, 2008

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2008 · 10.2K citations · Full text

Cancer Statistics, Epidemiology, Cancer Epidemiology +14

Methods in Mammalian Autophagy Research

Noboru Mizushima, Tamotsu Yoshimori, Beth Levine · Cell · 2010 · 4.5K citations · Full text

Cell Autophagy, Mitophagy, Autoantibody Production +6

Cancer immunotherapy: moving beyond current vaccines

Steven A. Rosenberg, James C. Yang, Nicholas P. Restifo · Nature Medicine · 2004 · 3K citations · Full text

Vaccination, Tumor Immunology, Cancer Immunosurveillance +9

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells

Giorgio Napolitani, Andrea Rinaldi, Francesco Bertoni et al. · Nature Immunology · 2005 · 1.1K citations · Full text

Inflammation, Toll-like Receptors, T Helper Type +11

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Sudha Singh, Alexander S. Davis, Gregory A. Taylor et al. · Science · 2006 · 902 citations

Host Response, Cell Autophagy, Mitophagy +15