A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTA Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase ActivityMichael S. Wolfe, Martin Citron, Thekla S. Diehl, Weiming Xia, Isaac O. Donkor, and Dennis J. SelkoeView Author Information Department of Pharmaceutical Sciences, University of Tennessee, Memphis, Tennessee 38163, and Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115 Cite this: J. Med. Chem. 1998, 41, 1, 6–9Publication Date (Web):January 1, 1998Publication History Received15 September 1997Published online1 January 1998Published inissue 1 January 1998https://pubs.acs.org/doi/10.1021/jm970621bhttps://doi.org/10.1021/jm970621brapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views893Altmetric-Citations188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Biopolymers,Inhibitors,Ketones,Monomers,Peptides and proteins Get e-Alerts