Concepedia

Simple and rapid determination of irinotecan and its metabolite SN-38 in plasma by high-performance liquid-chromatography: application to clinical pharmacokinetic studies

J. Escoriaza, Azucena Aldaz, C Castellanos, Emiliano Calvo, J. Giráldez

Journal of Chromatography B Biomedical Sciences and Applications · 2000 · 56 citations · 30 references

DOI

Concepts

References

30

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

, , +12

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

Yaw Huei Hsiang, Leroy F. Liu · PubMed · 1988 · 844 citations

, , +13

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

Robert Hertzberg, Mary Jo Caranfa, Sidney M. Hecht · Biochemistry · 1989 · 551 citations

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

E Gupta, Timothy M. Lestingi, Rosemarie Mick et al. · PubMed · 1994 · 506 citations

, , +21

Phase I and pharmacokinetic trial of weekly CPT-11.

Mace L. Rothenberg, John G. Kuhn, Howard A. Burris et al. · Journal of Clinical Oncology · 1993 · 301 citations

, , +13