Synthesis and antitumor activity of the hexacyclic camptothecin derivatives

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Camptothecin and Taxol:  Historic Achievements in Natural Products Research

Nicholas H. Oberlies, David J. Kroll · Journal of Natural Products · 2004 · 346 citations

Tumor Biology, Medicinal Chemistry, Refractory Ovarian Cancer +14

Molecular Modeling Studies of the DNA−Topoisomerase I Ternary Cleavable Complex with Camptothecin

Yi Fan, John N. Weinstein, Kurt W. Kohn et al. · Journal of Medicinal Chemistry · 1998 · 173 citations

Protein Assembly, Molecular Biology, Amber Force Field +17

The Novel Silatecan 7-<i>tert</i>-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

David Bom, Dennis P. Curran, Stefan Kruszewski et al. · Journal of Medicinal Chemistry · 2000 · 155 citations

Synthesis and Biological Evaluation of Novel A-Ring Modified Hexacyclic Camptothecin Analogues

Dae‐Kee Kim, Do Hyun Ryu, Ju Young Lee et al. · Journal of Medicinal Chemistry · 2001 · 78 citations · Full text

Bioorganic Chemistry, Chemoprevention Strategy, Organic Chemistry +18