Dae‐Kee Kim

Discovery of <i>N</i>-((4-([1,2,4]Triazolo[1,5-<i>a</i>]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1<i>H</i>-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): A Highly Potent, Selective, and Orally Bioavailable Inhibitor of TGF-β Type I Receptor Kinase as Cancer Immunotherapeutic/Antifibrotic Agent

Cheng Hua Jin, Maddeboina Krishnaiah, D. Sreenu et al. · Journal of Medicinal Chemistry · 2014 · 155 citations · Full text

Oral Bioavailability, Immunology, Pharmacotherapy +22

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation

Jeong-Hwan Yoon, Katsuko Sudo, Masahiko Kuroda et al. · Nature Communications · 2015 · 119 citations · Full text

Glia-dependent TGF-β signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis

Jian Luo, Peggy P. Ho, Marion S. Buckwalter et al. · Journal of Clinical Investigation · 2007 · 115 citations · Full text

EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis

Ji Yeon Son, So-Yeon Park, Sol‐Ji Kim et al. · Molecular Cancer Therapeutics · 2014 · 110 citations · Full text

Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor

Dae‐Kee Kim, Joonseop Kim, Hyun‐Ju Park · Bioorganic & Medicinal Chemistry Letters · 2004 · 85 citations

Medicine, Pharmacological Agent, Biological Evaluation +4