Some natural flavonoids are competitive inhibitors of caspase-1, -3, and -7 despite their cellular toxicity

Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

Saquib A. Lakhani, Ali J. Masud, Keisuke Kuida et al. · Science · 2006 · 1.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

The neuroprotective potential of flavonoids: a multiplicity of effects

David Vauzour, Katerina Vafeiadou, Ana Rodriguez‐Mateos et al. · Genes & Nutrition · 2008 · 550 citations · Full text

Medicine, Neuroscience, Pharmacology +12

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

Ing‐Kae Wang, Shoei‐Yn Lin‐Shiau, Jinxi Lin · European Journal of Cancer · 1999 · 460 citations

Life Sciences, Biochemistry, Pharmacology +13

Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties

Tina M. Caserta, A. N. Smith, Amy D. Gultice et al. · APOPTOSIS · 2003 · 403 citations

Life Sciences, Medicinal Chemistry, Pharmacology +9

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

Hagen Schroeter, Jeremy P. E. Spencer, Catherine Rice‐Evans et al. · Biochemical Journal · 2001 · 331 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17