Synthesis of a Hybrid Peptide with Both α- and β-Amino Acid Residues: Toward a New β-Sheet Nucleator

β‐Peptides: Synthesis by <i>Arndt‐Eistert</i> homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X‐ray crystallography. Helical secondary structure of a β‐hexapeptide in solution and its stability towards pepsin

Dieter Seebàch, Mark Overhand, Florian N. M. Kühnle et al. · Helvetica Chimica Acta · 1996 · 719 citations

Life Sciences, Biochemistry, Protein Biochemistry +16

β-Peptide Foldamers:  Robust Helix Formation in a New Family of β-Amino Acid Oligomers

Daniel H. Appella, Laurie A. Christianson, Isabella L. Karle et al. · Journal of the American Chemical Society · 1996 · 686 citations

Life Sciences, Biochemistry, Biophysics +13

Residue-based control of helix shape in β-peptide oligomers

Daniel H. Appella, Laurie A. Christianson, Daniel A. Klein et al. · Nature · 1997 · 622 citations

Life Sciences, Biochemistry, Molecular Biology +15

A short linear peptide that folds into a native stable β-hairpin in aqueous solution

Francisco J. Blanco, Germán Rivas, Luís Serrano · Nature Structural & Molecular Biology · 1994 · 530 citations

Life Sciences, Biochemistry, Biophysical Chemistry +13

Solution Structure of a Bovine Immunodeficiency Virus Tat-TAR Peptide-RNA Complex

Joseph D. Puglisi, Lily Chen, Scott C. Blanchard et al. · Science · 1995 · 342 citations

Life Sciences, Biochemistry, Molecular Biology +17