Concepedia

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

Arnab Ray Chaudhuri, Yoshitami Hashimoto, Raquel Herrador, Kai J. Neelsen, Daniele Fachinetti, Rodrigo Bermejo, Andrea Cocito, Vincenzo Costanzo, Massimo Lopes

Nature Structural & Molecular Biology · 2012 · 495 citations · 33 references

DOI

Concepts

References

33

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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Human CtIP promotes DNA end resection

Alessandro A. Sartori, Claudia Lukas, Julia Coates et al. · Nature · 2007 · 1.3K citations · Full text

, , +9

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

, , +17

Replicon Clusters Are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells

Dean A. Jackson, Ana Pombo · The Journal of Cell Biology · 1998 · 852 citations · Full text

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Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

José M. Sogo, Massimo Lopes, Marco Foiani · Science · 2002 · 821 citations

, , +17