Effects of Betulinic Acid Alone and in Combination with Irradiation in Human Melanoma Cells

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 881 citations

Tumor Biology, Human Melanoma, Medicine +11

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

Burkhard Jansen, Hermine Schlagbauer‐Wadl, Bob D. Brown et al. · Nature Medicine · 1998 · 487 citations

Melanoma, Scid Mice, Immune Checkpoint Inhibitor +5

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

Simone Fulda, Carsten Scaffidi, Santos A. Susín et al. · Journal of Biological Chemistry · 1998 · 372 citations · Full text

Mitophagy, Lipid Peroxidation, Apoptosis +17

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations

Mitochondrial Dysfunction, Apoptosis, Immunology +17

Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents

Yoshiki Kashiwada, Fumio Hashimoto, L. Mark Cosentino et al. · Journal of Medicinal Chemistry · 1996 · 272 citations · Full text

Pharmaceutical Science, Altmetric Attention Score, Pharmacotherapy +16