7α‐ and 7β‐Hydroperoxycholest‐5‐en‐3β‐ol in Muscle as Indices of Oxidative Stress: Response to Ethanol Dosage in Rats

Abstract

This is the first report on 7alpha-OOH and 7beta-OOH accumulation in rat skeletal muscle, and it seems to reflect greater oxidative stress in the pathology of muscle of rats treated with acute ethanol. Together with the elevation of 18:2, these results signify perturbations in membrane lipids in response to ethanol, which may have important implications for the pathogenesis of alcohol-induced muscle disorders.