The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chin Chiang, Ying Litingtung, Eric Lee et al. · Nature · 1996 · 3.1K citations

Biology, Knockout Mouse, Developmental Biology +6

Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants

Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science · 1997 · 1.7K citations

Knockout Mouse, Cell Lineage, Lineage Plasticity +13

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

James Chen, Jussi Taipale, Michael K. Cooper et al. · Genes & Development · 2002 · 1.5K citations · Full text

Signal Transduction, Fluorescent Derivatives, Biochemistry +14

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

Tito Serafini, Timothy E. Kennedy, Michael J. Gaiko et al. · Cell · 1994 · 1.4K citations

Molecular Neuroscience, Developmental Biology, Developmental Genetics +7

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

Timothy E. Kennedy, Tito Serafini, José R. de la Torre et al. · Cell · 1994 · 1.3K citations

Developmental Biology, Spinal Cord Injury, Neuroanatomy +12