A method to determine the incorporation capacity of camptothecin in liposomes

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

Life Sciences, Cell Biology, Molecular Biology +17

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

Yaw Huei Hsiang, Leroy F. Liu · PubMed · 1988 · 844 citations

Medicine, Molecular Biology, Pharmacology +12

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Robert Hertzberg, Mary Jo Caranfa, Kenneth G. Holden et al. · Journal of Medicinal Chemistry · 1989 · 414 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Development and characterization of a novel liposome-based formulation of SN-38

J.Allen Zhang, Tong Xuan, Manjeet M. Parmar et al. · International Journal of Pharmaceutics · 2003 · 219 citations

Pharmacy, Pharmaceutics, Pharmacology +11

Complete growth inhibition of human cancer xenografts in nude mice by treatment with 20-(S)-camptothecin.

B C Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski et al. · PubMed · 1991 · 178 citations

Medicine, Oncology, Pharmacology +14