Concepedia

Glucocorticoids increase CD4<sup>+</sup>CD25<sup>high</sup>cell percentage and Foxp3 expression in patients with multiple sclerosis

Manjit Braitch, Sreedharan Harikrishnan, R. A. Robins, C. Nichols, A. J. Fahey, Louise C. Showe, Cris S. Constantinescu

Acta Neurologica Scandinavica · 2008 · 97 citations · 26 references

DOI

Abstract

Results suggest that glucocorticoids increase Treg cell functional molecules and percentages. This may be a mechanism whereby steroids expedite recovery from MS relapses.

References

26

Rating neurologic impairment in multiple sclerosis

John F. Kurtzke · Neurology · 1983 · 14.7K citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter et al. · Nature Immunology · 2010 · 5.8K citations · Full text

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Shimon Sakaguchi, N Sakaguchi, M Asano et al. · The Journal of Immunology · 1995 · 5.4K citations

Toll Pathway-Dependent Blockade of CD4 <sup>+</sup> CD25 <sup>+</sup> T Cell-Mediated Suppression by Dendritic Cells

Chandrashekhar Pasare, Ruslan Medzhitov · Science · 2003 · 2K citations

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Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

Vissia Viglietta, Clare Baecher‐Allan, Howard L. Weiner et al. · The Journal of Experimental Medicine · 2004 · 1.8K citations · Full text

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