Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

The rat brain in stereotaxic coordinates

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Brain Structure, Neurophysiology, Neuroanatomy +7

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Jens C. Brüning, Dinesh Gautam, Deborah J. Burks et al. · Science · 2000 · 2.2K citations

Insulin Receptors, Food Intake, Insulin Signaling +19

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

Robert Frederich, A. Hamann, Stephen Anderson et al. · Nature Medicine · 1995 · 1.7K citations

Obesity, Metabolic Syndrome, Animal Physiology +12