Luciano Rossetti

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

Xue-Liang Du, Diane Edelstein, Luciano Rossetti et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Terry P. Combs, Anders H. Berg, Silvana Obici et al. · Journal of Clinical Investigation · 2001 · 901 citations · Full text

Metabolic Remodeling, Insulin Signaling, Obesity +17

Hypothalamic insulin signaling is required for inhibition of glucose production

Silvana Obici, Bei B. Zhang, George B. Karkanias et al. · Nature Medicine · 2002 · 856 citations

Obesity, Metabolic Syndrome, Energy Homeostasis +13

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

Jiali Wang, Rong Liu, Meredith Hawkins et al. · Nature · 1998 · 837 citations

Metabolic Syndrome, Energy Homeostasis, Molecular Physiology +12

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

Luciano Rossetti, Douglas J. Smith, Gerald I. Shulman et al. · Journal of Clinical Investigation · 1987 · 803 citations · Full text

Insulin Resistance, Metabolic Syndrome, Glucose Tolerance +15