A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Jeffrey L. Halaas, K.S. Gajiwala, Margherita Maffei et al. · Science · 1995 · 4.5K citations

Medicine, Endocrinology, Nutritional Sciences +17

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Mary Ann Pelleymounter, Mary Jane Cullen, Mary Baker et al. · Science · 1995 · 4K citations

Life Sciences, Biochemistry, Endocrinology +17

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

L. Arthur Campfield, Françoise J. Smith, Yves Guisez et al. · Science · 1995 · 3.3K citations

Life Sciences, Neurobiology, Neuroscience +17

Role of leptin in the neuroendocrine response to fasting

Rexford S. Ahima, Daniel Prabakaran, Christos S. Mantzoros et al. · Nature · 1996 · 3.1K citations

Life Sciences, Endocrinology, Physiology +11