2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Roy A. Black, Charles T. Rauch, Carl J. Kozlosky et al. · Nature · 1997 · 3.1K citations

Inflammation, Medicine, Metalloprotein +6

Targeting TACE-dependent EGFR ligand shedding in breast cancer

Paraic A. Kenny, Mina J. Bissell · Journal of Clinical Investigation · 2007 · 250 citations · Full text

Breast Oncology, Protease-dependent Autocrine Loop, Tgfa Expression +9

TACE and other ADAM proteases as targets for drug discovery

Marcia L. Moss, Judith M. White, Millard H. Lambert et al. · Drug Discovery Today · 2001 · 155 citations

Chemical Biology, Protein Function, Drug Target +7

Biology of TACE inhibition

Robert Newton, Kimberly A. Solomon, Maryanne Covington et al. · Annals of the Rheumatic Diseases · 2001 · 100 citations · Full text

Immunology, Pathology, Cell Death +22

Discovery and SAR of hydantoin TACE inhibitors

Wensheng Yu, Zhuyan Guo, Peter Orth et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 56 citations · Full text

Medicinal Chemistry, Drug Target, Medicine +5