TACE and other ADAM proteases as targets for drug discovery

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Roy A. Black, Charles T. Rauch, Carl J. Kozlosky et al. · Nature · 1997 · 3.1K citations

Inflammation, Medicine, Metalloprotein +6

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

Marcia L. Moss, S.-L. Catherine Jin, Marcos E. Milla et al. · Nature · 1997 · 1.6K citations

Protein Expression, Medicine, Disintegrin Metalloproteinase +8

An Essential Role for Ectodomain Shedding in Mammalian Development

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Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

Neurodegenerative Diseases, Protein Secretion, Molecular Neuroscience +8