Concepedia

Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

Stephen R. Bertenshaw, John J. Talley, D. Joseph Rogier, Matthew J. Graneto, Carol M. Koboldt, Yan Zhang

Bioorganic & Medicinal Chemistry Letters · 1996 · 42 citations · 11 references

DOI

Concepts

References

11

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

, , +10

Aspirin Selectively Inhibits Prostaglandin Production in Human Platelets

J. Bryan Smith, A.L. Willis · Nature New Biology · 1971 · 1.5K citations

, , +14

Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs

M C Allison, Allan G. Howatson, Caroline J. Torrance et al. · New England Journal of Medicine · 1992 · 962 citations · Full text

, , +11

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

Nobuko Futaki, Satoru Takahashi, Motofumi Yokoyama et al. · Prostaglandins · 1994 · 833 citations

, , +14

Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.

Kathleen R. Gans, W Galbraith, Richard J. Roman et al. · Journal of Pharmacology and Experimental Therapeutics · 1990 · 230 citations

, , +16