The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

John R. Riordan, Johanna M. Rommens, Bat-Sheva Kerem et al. · Science · 1989 · 7.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

Johanna M. Rommens, Michael C. Iannuzzi, Bat-Sheva Kerem et al. · Science · 1989 · 3.2K citations

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

Seng H. Cheng, Richard J. Gregory, John Marshall et al. · Cell · 1990 · 1.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Degradation of CFTR by the ubiquitin-proteasome pathway

Cristina L. Ward, Satoshi ŌMURA, Ron R. Kopito · Cell · 1995 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

Gerene M. Denning, Matthew P. Anderson, Jane F. Amara et al. · Nature · 1992 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +9