Concepedia

Post-translational Folding

Post-Translational Folding is a molecular process in which newly synthesized polypeptides undergo structural organization into their native conformations after release from the ribosome, typically facilitated by molecular chaperones that prevent aggregation and promote correct folding in the absence of translational coupling.

119

Publications

9.5K

Citations

495

Authors

199

Institutions

Publications per year

2017–2026

26

Parents

Publications

119

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

Judith Frydman, Elmar Nimmesgern, Kenzo Ohtsuka et al. · Nature · 1994 · 656 citations

, , +16

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

Gong Zhang, Magdalena Hubalewska, Zoya Ignatova · Nature Structural & Molecular Biology · 2009 · 565 citations

, , +14

Recombination of protein domains facilitated by co-translational folding in eukaryotes

William J. Netzer, F. Ulrich Hartl · Nature · 1997 · 410 citations

, , +14

In vivo newly translated polypeptides are sequestered in a protected folding environment

Vanitha Thulasiraman, Chin‐Fen Yang, Judith Frydman · The EMBO Journal · 1999 · 362 citations · Full text

, , +12

The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR

Kai Du, Manu Sharma, Gergely L. Lukács · Nature Structural & Molecular Biology · 2004 · 357 citations

, , +16

1–5 of 119

Authors

495

  1. GV
    Gunnar von Heijne

    Stockholm University, Sweden

    6 publications · 472 citations

    6

    h-index

  2. FU
    F. Ulrich Hartl

    Max Planck Institute of Biochemistry, Germany

    6 publications · 1.5K citations

    6

    h-index

  3. EP
    Edward P. O’Brien

    Pennsylvania State University, United States

    6 publications · 546 citations

    6

    h-index

  4. PL
    Patricia L. Clark

    University of Notre Dame, United States

    4 publications · 277 citations

    4

    h-index

  5. MS
    Matti Sarvas

    Institute for Molecular Medicine Finland, Finland

    4 publications · 321 citations

    4

    h-index

1–5 of 495

Institutions

199

  1. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    30 publications

    832 citations

  2. Stockholm University

    Stockholm, Sweden

    6 h-index

    27 publications

    1.9K citations

  3. Science for Life Laboratory

    Stockholm, Sweden

    5 h-index

    6 publications

    393 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    13 publications

    3.5K citations

  5. Max Planck Institute of Biochemistry

    Martinsried, Germany

    5 h-index

    20 publications

    4K citations

  6. Pennsylvania State University

    State College, United States

    5 h-index

    16 publications

    1.1K citations

  7. Yale University

    New Haven, United States

    4 h-index

    9 publications

    893 citations

  8. Birkbeck, University of London

    London, United Kingdom

    4 h-index

    8 publications

    565 citations

1–8 of 199

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 1K citations

    15

    h-index

  2. Journal of Molecular Biology

    JMB · 8 publications · 462 citations

    8

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 512 citations

    6

    h-index

  4. Science

    5 publications · 866 citations

    5

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 4 publications · 263 citations

    4

    h-index

1–5