Kai Du

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

Tsukasa Okiyoneda, Hervé Barrière, Miklós Bagdány et al. · Science · 2010 · 407 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR

Kai Du, Manu Sharma, Gergely L. Lukács · Nature Structural & Molecular Biology · 2004 · 357 citations

Life Sciences, Genetics, Molecular Biology +16

Misfolding diverts CFTR from recycling to degradation

Manu Sharma, Francesca Pampinella, Csilla Nemes et al. · The Journal of Cell Biology · 2004 · 325 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

Wael M. Rabeh, Florian Bossard, Haijin Xu et al. · Cell · 2012 · 291 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +15

Nanomolar Affinity Small Molecule Correctors of Defective ΔF508-CFTR Chloride Channel Gating

Hong Yang, Anang A. Shelat, R. Kiplin Guy et al. · Journal of Biological Chemistry · 2003 · 203 citations · Full text

Natural Sciences, Medicinal Chemistry, Molecular Biology +13